LONGEVITY Synergistic Ingredients
Olive Polyphenols prevent and repair cellular damage caused by free radicals, prevent oxidation of low density lipoproteins, reduce the risk of coronary heart disease, improve glucose metabolism and skin health. More recently, studies have revealed that olive polyphenols are related also other important activities including anti-amyloidogenic activity, cell signaling modulation, effects on telomere length and modulation of the sirtuin proteins. Olive Polyphenols are able to cross the blood—brain barrier with multiple effects on pathways involved in neurodegeneration and ageing may be proven efficacious in the treatment of age-related diseases such as Alzheimer’s disease.
Resveratrol a powerful polyphenol found in several types of plants, including red grapes, blueberries, and nuts. Resveratrol works inside every cell in the body to help rejuvenate the mitochondria, the powerhouses that keep cells functioning properly.
Scientific evidence suggests that it can also help promote healthy aging in humans and animals. Several lab studies have shown that it may improve cellular health, in particular by activating sirtuins Resveratrol is drawing a lot of attention in the scientific community with over 1100 studies published in 2016 alone; the total number of publications on resveratrol now exceeds 10,000, making it one of the fastest growing bodies of evidence for a health and wellness ingredient. This published research and clinical data suggests that resveratrol can play a role in healthy aging through maintaining bone health, cardiovascular health, blood glucose control, healthy cognitive function, skin youthfulness and oral health.
Pomegranates can help prevent or treat various disease risk factors including high blood pressure, high cholesterol, oxidative stress, hyperglycemia, and inflammatory activities. It is demonstrated that certain components of pomegranate such as polyphenols have potential antioxidant, anti-inflammatory, and anticarcinogenic effects. The antioxidant potential of pomegranate is more than that of red wine and green tea, which is induced through ellagitannins and hydrosable tannins. Pomegranate can reduce macrophage oxidative stress, free radicals, and lipid peroxidation. Moreover, pomegranate fruit extract prevents cell growth and induces apoptosis, which can lead to its anticarcinogenic effects. In addition, promoter inhibition of some inflammatory markers and their production are blocked via ellagitannins.
The dietary consumption of grape and its products is associated with a lower incidence of degenerative diseases such as cardiovascular disease and certain types of cancers. Most recent interest has focused on the bioactive phenolic compounds in grape. Anthocyanins, flavanols, flavonols and resveratrol are the most important grape polyphenols because they possess many biological activities, such as antioxidant, cardioprotective, anticancer, anti-inflammation, antiaging and antimicrobial properties.
K-age™ is an innovative proprietary synergistic complex obtained from Polygonum cuspidatum and Olea europea which provides biologically enhanced trans-Resveratrol. K-age™ aims to prevent and repair cellular damage caused by free radicals, protects cells from Oxidative stress, stimulates the regeneration of cells and prevents the accumulation of damaged components in the cell by increasing proteasome levels and decreasing the levels of oxidized proteins.
Vitamin B3 ( Niacin)
Clinical research demonstrates that Niacin, is a highly efficient precursor to NAD+. Incorporating Niacin into the body has been shown to restore NAD+ levels in laboratory models, combating age-related decline in the NAD+ supply that cells experience. Preclinical studies link the restoration of NAD+ supplies to an improvement in metabolic efficiency and overall health.